The effects of Nω-nitro-L-arginine methyl ester, sodium nitroprusside and noradrenaline on venous return in the anaesthetized cat
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منابع مشابه
Episcleral venous pressure responses to topical nitroprusside and N-Nitro-L-arginine methyl ester.
PURPOSE To determine the episcleral venous pressure (EVP) responses to nitroprusside (NP) and L-NAME. METHODS In anesthetized rabbits (n = 36), arterial pressure and IOP were measured by direct cannulation, and carotid blood flow and heart rate were measured with an ultrasound flowmeter and cardiotachometer. EVP was measured in two groups with a servonull system. Group 1 (n = 13) was given NP...
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Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure.
The dose-dependent effects of intravenous infusions of nitric oxide (NO) synthesis inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 0.1, 1, 10, and 50 micrograms.kg-1.min-1), were studied in anesthetized rats to determine whether the inhibitory actions of L-NAME are manifested primarily in alterations of renal function or whether they are the consequences of the increase in systemic blood p...
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BACKGROUND Long-term inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-)) are protected against L-NAME-induced pathologies. In this study, ...
متن کاملN-nitro-L-arginine methyl ester influence on aluminium toxicity in the brain.
We investigated the influence of a non-specific nitric oxide synthase (NOS) inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on brain nitrite concentration and acetylcholine esterase activity in AlCl3-treated Wistar rats. Animals were killed 10 min, three hours, three days and 30 days after the treatment and hippocampus and basal forebrain were removed. The biochemical changes observed in n...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1993
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1993.tb13489.x